Testosterone Therapy: Is It Your Path to Better Health?

Dr. Ryan Tubre, Board Certified Urologist owner of Rose City Urology in Tyler, Texas
Dr. Ryan Tubre

Publish Date:

October 2, 2025

Understanding Urology: The Medical Specialty Focused on the Urinary Tract

Why Understanding HRT for Men Matters for Your Health

HRT for men (Hormone Replacement Therapy) is a medical treatment that supplements declining testosterone levels to manage symptoms like fatigue, reduced libido, and muscle loss.

Key Facts About HRT for Men:

  • What it treats: Low testosterone (hypogonadism) and age-related hormone decline.
  • Common symptoms: Decreased energy, reduced sex drive, erectile dysfunction, mood changes, and muscle loss.
  • Treatment methods: Injections, gels, patches, and pellets.
  • Best candidates: Men with confirmed low testosterone and bothersome symptoms.
  • Timeline: Energy improvements in weeks; muscle/bone changes take months.
  • Monitoring required: Regular blood tests and medical supervision.

Men over 30 lose about 1-1.5% of their testosterone annually. This natural decline can significantly impact your quality of life. The decision to pursue HRT isn't just about aging gracefully—it's about maintaining your health and vitality. Understanding your options is the first step toward feeling like yourself again.

I'm Dr. Ryan Tubre, a board-certified urologist at Rose City Urology in Tyler, Texas. I specialize in HRT for men, helping patients steer hormone health with personalized treatment plans to restore vitality.

Infographic showing testosterone decline in men starting at age 30, with levels dropping 1-1.5% annually, and common symptoms appearing in 40s and 50s including fatigue, reduced libido, muscle loss, mood changes, and erectile dysfunction - HRT for men infographic

Understanding Low Testosterone (Hypogonadism)

Low testosterone, or hypogonadism, occurs when your body doesn't produce enough of this key hormone. While levels naturally decline about 1% per year after age 30, a significant drop can impact your daily life. This condition is common, affecting 19% of men in their 60s, and the prevalence increases with age. Recognizing the signs is the first step toward addressing the issue.

Man experiencing symptoms like fatigue and brain fog - HRT for men

What are the Signs of Low Testosterone?

Many men mistake the subtle onset of low testosterone symptoms for normal aging. Pay attention if you experience several of the following:

  • Decreased sex drive and erection difficulties.
  • Persistent fatigue that sleep doesn't resolve.
  • Mood changes, such as irritability, sadness, or depression.
  • Reduced muscle mass and strength, despite regular exercise.
  • Increased body fat, especially around the midsection.
  • Hair loss (body and facial) and bone density loss.

If these symptoms sound familiar, you're not alone; testosterone deficiency affects about 1 in 200 men. Learn more from our guide on Low Testosterone.

How is Low Testosterone Diagnosed?

Diagnosing low testosterone requires a thorough approach to get a full picture of your hormone health. The process includes:

  • A detailed medical history and physical examination to discuss symptoms and assess overall health.
  • Blood testing to measure total and free testosterone, as well as Luteinizing Hormone (LH). Since testosterone levels peak in the morning, your blood draw is scheduled between 7 a.m. and 10 a.m. for accuracy.
  • Multiple tests on different days are often needed to confirm consistently low levels. A man may be diagnosed with hypogonadism if total testosterone is less than 300 ng/dl.

For older men with symptoms, many specialists consider HRT for men when total testosterone falls below 300 ng/dl. This careful process ensures an accurate diagnosis. For more, see this scientific research on hypogonadism.

What is HRT for Men and Is It Right for You?

HRT for men, or Hormone Replacement Therapy, restores hormones your body is no longer making in sufficient amounts. Most often, this means Testosterone Replacement Therapy (TRT), which aims to bring testosterone levels back to a healthy range. The key question is whether you have a medical need for it, or are simply experiencing normal age-related changes. At Rose City Urology, we help you determine the right path for your health.

Doctor consulting with a male patient - HRT for men

Not all low testosterone is the same. True hypogonadism is a medical condition where the testicles or pituitary gland malfunction, impairing hormone production. In this case, treatment is often necessary.

Age-related decline, sometimes called andropause, is the natural, gradual drop in testosterone after age 30. The FDA does not recommend testosterone products just to treat the normal effects of aging due to potential health risks. You can read The FDA's stance on TRT for aging for more information. Our job is to determine if your symptoms are from a medical condition or normal aging.

Who is a Good Candidate for Treatment?

An ideal candidate for HRT for men is someone who will see clear benefits safely. We look for a combination of factors:

  • Significant symptoms that negatively impact your quality of life, such as persistent fatigue, low libido, or mood changes.
  • Confirmed low testosterone levels from multiple blood tests.
  • Good overall health with no conditions that would make testosterone therapy risky.
  • Essential screenings, including a PSA test for prostate health and a cardiovascular health assessment.

Men with active prostate cancer, untreated severe sleep apnea, uncontrolled heart failure, or a history of blood clots are generally not good candidates. Our goal is to ensure HRT for men is a life-changing fit, not a one-size-fits-all solution.

The Potential Benefits and Risks of Testosterone Therapy

Deciding to start HRT for men requires a clear understanding of the potential benefits and risks. Every medical treatment has trade-offs, and our goal is to provide a complete picture so you can make an informed choice. We take a comprehensive approach to Men's Urologic Health to ensure the best outcome for you.

Balanced scale representing benefits vs. risks - HRT for men

The Upside: Potential Health Benefits

For the right candidate, HRT for men can lead to transformative improvements:

  • Increased energy: Fatigue often lifts within weeks.
  • Improved libido and sexual function: Desire and performance can return, improving relationships.
  • Better mood: Irritability, anxiety, and low feelings may clear, improving overall well-being.
  • Increased muscle mass and strength: The body responds better to exercise.
  • Improved bone density: Reduces long-term fracture risk, with studies showing significant gains.
  • Better focus and cognitive function: Many men report clearer thinking and reduced "brain fog." Research on cognitive function benefits explores these effects.
  • Fat reduction: Can help improve body composition, especially with a healthy lifestyle.

The Downside: Potential Risks and Side Effects

With careful monitoring, most risks can be managed or avoided. Potential side effects include:

  • Skin issues: Acne and oily skin, usually temporary.
  • Fluid retention: Mild puffiness, especially in the ankles.
  • Worsening sleep apnea: A potential concern for those with a pre-existing condition.
  • Decreased sperm production and infertility: A critical consideration for men planning to have children.
  • Testicular shrinkage: A natural response as the body reduces its own testosterone production.
  • Nipple Tenderness
  • Increased red blood cell count: Can thicken blood, increasing clot risk. Regular blood work is essential for monitoring.
  • Cardiovascular risks: Research is mixed, making individual risk assessment crucial. See a review of cardiovascular risks.
  • Prostate health concerns: Requires regular monitoring of PSA levels, as the relationship between testosterone and prostate health is complex.

Starting HRT for men is a carefully planned journey. At Rose City Urology, we partner with you to create a personalized treatment plan custom to your body, symptoms, and lifestyle. This process begins with a consultation with a specialist, like a urologist or endocrinologist, to ensure you receive expert care. Your plan will be unique, as what works for one person may not be the best fit for another. Learn more about our approach to Men's Hormone Replacement Therapy.

Common Administration Methods for HRT for men

We will work together to choose the best delivery method for you:

  • Intramuscular injections: A cost-effective option given every 1-2 weeks. Energy levels may fluctuate between doses.
  • Transdermal gels: A daily application that provides steady hormone levels. Care must be taken to avoid skin-to-skin contact with others until it dries.
  • Skin patches: Changed daily or every few days, offering convenience but may cause skin irritation for some.
  • Subdermal pellets: A long-lasting option where pellets are inserted under the skin every 5 months, offering a "set it and forget it" approach.

Monitoring and Alternatives to HRT for men

Ongoing monitoring is key to successful treatment. Regular blood work is used to track hormone levels, red blood cell count, and Prostate-Specific Antigen (PSA) levels to ensure safety and effectiveness.

However, HRT for men isn't always the only answer. Lifestyle changes can produce remarkable improvements, sometimes even replacing the need for therapy:

  • Diet and Exercise: A healthy diet and regular strength training can naturally boost testosterone.
  • Weight Loss: Losing excess weight can significantly improve hormone levels.
  • Stress Management and Sleep Hygiene: Reducing stress and getting quality sleep are crucial, as both directly impact hormone production.

These strategies can be used alone or to complement hormone therapy, giving your body every advantage.

Understanding Low Testosterone (Hypogonadism)

Hypogonadism is a medical condition where the body doesn't produce enough testosterone to function optimally. While levels naturally decline about 1% per year after age 30, a significant drop can cause unwelcome changes. Studies show it affects 19% of men in their 60s, with the rate increasing with age. Recognizing the signs is the first step toward seeking help.

What are the Signs of Low Testosterone?

Symptoms can be subtle and are often dismissed as normal aging. A combination of these signs warrants investigation:

  • Decreased sex drive and erection difficulties.
  • Loss of energy and persistent fatigue.
  • Depressed mood, irritability, or sadness.
  • Reduced muscle mass and strength.
  • Increased body fat, particularly around the abdomen.
  • Hair loss and reduced bone density.

These symptoms affect approximately 1 in 200 men. For more detailed information on these symptoms, please visit our page on Low Testosterone.

How is Low Testosterone Diagnosed?

Diagnosis is a thorough process involving a medical history review, a physical exam, and blood tests. We measure total testosterone, free testosterone, and Luteinizing Hormone (LH). For accuracy, blood is drawn in the morning (7-10 a.m.) when levels are highest. We often require at least two tests on different days to confirm low levels. A man may be considered hypogonadal if total testosterone is below 200 ng/dl. For older men with symptoms, treatment may be considered if levels are below 300 ng/dl. You can find more Scientific research on Hypogonadism here.

What is HRT for Men and Is It Right for You?

HRT for men, or Hormone Replacement Therapy, is a medical treatment to restore testosterone levels, often called Testosterone Replacement Therapy (TRT). The goal is to alleviate symptoms of low testosterone and improve well-being. The decision to start HRT requires careful consideration of medical necessity versus a lifestyle choice.

It's crucial to distinguish between two scenarios:

  • Hypogonadism: A medical condition where the testicles or pituitary gland fail to produce enough testosterone. Here, HRT is often medically necessary.
  • Age-related decline: The natural, gradual decrease in testosterone with age. There can be benefit from treating the age related decline when it comes to prevention of chronic medical diseases.  This can be discussed specifically with your physician.

Our role is to help you determine if your symptoms stem from a medical condition or the natural aging process.

Who is a Good Candidate for Treatment?

A good candidate for HRT for men typically has:

  • Bothersome symptoms consistent with low testosterone.
  • Consistently low testosterone levels confirmed by blood tests.
  • A comprehensive health evaluation confirming the therapy is safe for them.
  • No contraindications, such as active prostate cancer, untreated severe sleep apnea, or uncontrolled heart failure.

We perform prostate and cardiovascular screenings before and during therapy to ensure it is both effective and safe for your long-term health.

The Potential Benefits and Risks of Testosterone Therapy

Starting on any medical treatment, especially one involving hormone modulation, requires an informed decision. We believe in transparency, thoroughly discussing both the potential upsides and the potential downsides of HRT for men to help you weigh the pros and cons. Our personalized treatment plans are designed to maximize benefits while carefully managing risks. You can learn more about general Men's Urologic Health on our website.

The Upside: Potential Health Benefits

When appropriately prescribed and monitored, HRT for men can lead to significant improvements in various aspects of your health and well-being.

The potential benefits include:

  • Increased energy and reduced fatigue.
  • Improved libido and sexual function.
  • Better mood and reduced irritability or depression.
  • Increased muscle mass and strength.
  • Improved bone density, reducing the risk of osteoporosis and fractures.
  • Better focus and cognitive function. You can explore more Research on cognitive function benefits.
  • Fat reduction and improved body composition.
  • Metabolic health, as testosterone can help manage conditions such as diabetes.

The Downside: Potential Risks and Side Effects

Like any medical treatment, HRT for men carries potential risks and side effects. We ensure you are fully aware of these and are continuously monitored to mitigate them.

Some potential risks and side effects include:

  • Acne and oily skin.
  • Fluid retention.
  • Worsening sleep apnea.
  • Decreased sperm production and infertility.
  • Testicular shrinkage.
  • Gynecomastia (the development of breast tissue).
  • Increased red blood cell count, which can thicken the blood and increase the risk of clots.
  • Cardiovascular risks: There is ongoing debate regarding the effects of HRT on heart health. See A review of cardiovascular risks.
  • Prostate health concerns: The impact of HRT on the prostate is complex, requiring regular monitoring.

We will discuss these risks in detail with you, tailoring your treatment plan to your unique health profile.

Starting HRT for men is a partnership focused on restoring your vitality and well-being. At Rose City Urology, we create a treatment plan that's specifically custom to your symptoms, health history, and lifestyle. Your journey begins with a comprehensive consultation with a specialist to ensure you receive expert care. For more detailed information about our approach, visit our page on Men's Hormone Replacement Therapy.

Table comparing HRT administration methods - HRT for men infographic brainstorm-4-items

Common Administration Methods for HRT for men

One of the first important decisions we'll make together is choosing how to deliver your HRT for men:

  • Testosterone injections: Given every 1-2 weeks, they are highly effective and cost-efficient, but may cause energy fluctuations.
  • Transdermal gels: Applied daily, they deliver a steady dose but require care to prevent accidental transfer to others.
  • Skin patches: Convenient and discreet, but can cause skin irritation for some users.
  • Subdermal pellets: A long-lasting option inserted every 3-6 months, but dose adjustments require a minor procedure.

Monitoring and Alternatives to HRT for men

Once you start HRT for men, regular monitoring is crucial for safety and fine-tuning your treatment. Regular blood work tracks hormone levels, red blood cell count, and PSA levels for prostate health.

HRT for men isn't always the only answer. Lifestyle changes can work wonders:

  • Diet and exercise: A balanced diet and resistance training can naturally boost testosterone.
  • Weight loss: Losing excess weight can restore testosterone levels naturally.
  • Good sleep and stress management: These are crucial for healthy hormone production.

These strategies can work alone or make your hormone therapy more effective. We believe in giving your body every advantage possible.

Frequently Asked Questions about Testosterone Therapy

It's natural to have questions when considering HRT for men. Here are answers to some of the most common concerns we hear at Rose City Urology.

How long does it take to see results from TRT?

Results appear gradually. While HRT for men isn't an overnight fix, many men notice improvements on this general timeline:

  • Sexual desire: Often improves within 3 to 6 weeks.
  • Energy and mood: You may feel better within a few weeks to a few months.
  • Physical changes: Increased muscle mass and bone density typically become noticeable after 3 to 6 months, with continued improvement for up to a year.

Timelines vary for each individual, but consistency is key to achieving the best results.

Can testosterone therapy stop or reverse aging?

No, HRT for men is not a fountain of youth and cannot reverse the aging process. However, it can effectively treat the specific symptoms caused by a testosterone deficiency. By restoring hormone levels, it can help you feel more energetic, vital, and like your old self again. The goal is not to reverse aging, but to optimize your health and improve your quality of life at any age.

Will HRT affect my fertility?

Yes, this is a critical consideration. HRT for men signals your brain to reduce the hormones needed for sperm production, which can lead to a significantly lower sperm count and infertility. While this effect can be temporary, reversal is not guaranteed after stopping therapy. If you plan on having children in the future, it is essential to discuss this with us before starting treatment. We can explore alternatives or options like sperm banking to preserve your fertility.

Take Control of Your Health

You've learned about the signs of low testosterone and how HRT for men can help you reclaim your vitality. While not a magic solution, for the right person, it can be life-changing—restoring energy, confidence, and well-being.

Having the right medical team is crucial. At Rose City Urology in Tyler, Texas, we reject one-size-fits-all approaches. We provide thorough evaluations and develop personalized treatment plans that fit your unique health goals and lifestyle. Our commitment is to monitor your progress, ensure your safety, and provide expert guidance, whether you choose HRT or focus on lifestyle changes.

If you're experiencing symptoms like persistent fatigue or reduced libido, don't dismiss them as just "getting older." You deserve to feel your best.

Ready to explore if HRT for men is right for you? Let's talk about your concerns and find your path to better health.

Contact Us to schedule a consultation

HELP IS AVAILABLE

We aim to restore your quality of life

At Rose City Urology, we aim to treat the most common to the most complex conditions to help you get back to living your best.